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AK raised pre-flop, as overpairs with a gutshot on the flop tends to play pretty well unless someone raises back at you. Generally you are going to have 10 outs plus some fold equity, which makes it a very good spot for a c-bet.
As for gutshots in general, pot and implied odds are extremely important here. If you raised pre-flop or you think the other players in the hand are weak, or you are heads up, you can certainly fire a c-bet. Otherwise, you need to have in mind what sort of payoff you can expect if you hit one of your 4 outs. So check the other players' stack sizes and think about how much you will be able to get them to put into the pot if you hit your draw.
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