It depends on a lot of different factors. One place to start is that you can't just use the logic that you'll play a range that has 50% equity against his range because that would mean you have hands in your range that are less than 50% against his. You're also not accounting for position and the fact that equity isn't the same thing as EV.

I would suggest starting with the 3-betting game. There are threads in the SSNL digest that show how to do this as well as in my strategy anthology sticky in SSNL.