In general, the less popular the game, the greater an edge you can find if you put in the time and effort to study the game. The more players in a game, the more active study and general knowledge will be in those communities.

If you're in poker for the money, it is to your great advantage to learn those less popular games and to study them. The relative skill advantage you will have over the other players is greater for your invested time. The only problem is finding a table, then. Table selection tends to be less of an issue, but if there's only 1 table playing and you know you're the fish to at least 2 of the player already sitting, then just don't sit at that table. Watch and learn if you're in the mood, or just find another game to play where you've got a better edge against the table.