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The essential difference is that 6max has fewer seats at the table. I know you think I'm being a wiseass, but that's all there is. Fewer seats at the table makes for three key strategic implications:
1. The BTN comes around faster.
2. Position changes faster.
3. There are fewer starting combos dealt each hand.
I know you're rolling your eyes, but think about what each of these things means. Sir Pawn is right about the cost/hand, but let's face it: EVERY piece of info out there about 6max talks about the blinds "coming around faster" and how that means you have play more hands. Thus, the game appeals to the action-hounds who happily just play 10% more hands from every position. But the fact the blinds come around faster is almost irrelevant. Everyone is equally disadvantaged by the blinds.
The key to beating 6max is to maximally profit from the BTN and CO coming around faster.
That's the point of #2 that most people miss. The person who wins most at 6max is the one who can play each position at the table differently, adjusting more to opponents/position. Most 6m regs only understand position in terms of "stealing more" from the BTN and (sometimes) the CO/SB. There's more to the power of position than blind steals, and we can profit from understanding position and using it better (even EP!! / oop) than our opponents do.
Most 6m regs seem to misinterpret #3 as meaning "fewer great hands are out against you," and therefore they just "open up" from all positions and play more hands. They weaken their range. But the reason #3 is vital is because we end up in HU pots much more routinely in 6m than in FR. So when our opponents just play more loosely, but fail to adjust to the essential nature of the game, they give us real opportunities to make precision reads on their game and play a "optimal exploiting game" against them.
In FR, you manage to isolate less, and you can't play exploitative lines against single opponents as often. With fewer seats at 6m, you get a chance to play HU nearly every time you see a flop. So reads and non-standard exploitative lines become extremely valuable.
And that relates to #2: we can more easily play exploitative lines when in position. And our ability to specifically adjust to various opponents from different positions and PLAY VERY DIFFERENTLY AGAINST EACH ONE stems from the fact that there are fewer seats at the table.
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