There is really little difference between players from 10nl - 50nl. bluff less (bluffing is overated anyway) fold when in doubt. get PT and HUD and don't make a move on anyone without a read and stats to back it up.

Assuming you play 2-4 tables ( playing just one table is a waste and boredom gets you in trouble), Open your normal 10nl tables but replace one with a 25nl and play all the same.