You can do this with HEM, and it should be possible with PT as well. From a high level, you just need to install your database on a portable drive.

You can also set it up across a local network. Obviously, set up the database on your laptop locally (so you always have it with you) then set up your desktop to access it via the local network:

http://www.pokertracker.com/forums/v...hp?f=45&t=4638