A little bit of general theoretical question. I realize that big slick is a nice hand to have and should be bet pre-flop quite nicely, as effectively only AA and KK have more chances winning it pre-flop (I consider any other pair to be a coinflip, though it is not pure 50/50).

Though I am a bit stuck on how to play AK after you see the flop and miss it (something like QhTs4c), especially when your opponent acts aggressively both pre-flop and after he sees the flop (when he is passive out of position, I would bet at least 1/2 pot, but what you do when he is in position and raises my bet substantially?).

My point is that you effectively have 6 outs (or 24% to win) before the turn and if someone bets heavily into you on the flop (indicating he's got at least a pair of whatever), should you fold AK or still hold to it just because it is a big slick?