Wellllll...
I prefer OESD's to flush draws, as they are better disguised (usually) and you will get paid more often. Semi-disciplined opponents won't pay off flushes but will pay off straights quite a bit. Basically, I go off the pure pot odds with flush draws, but with straight draws (especially unusual ones) I'll nudge the figures according to how much they have left, and how much of that I think I can get. Pre-flop I wouldn't want to call huge raises, unless both of our stacks are also huge, because the implied value has to be there. I worked this out one time - I believe with suited connectors you'll get a valuable hand on the flop about 25% of the time. That's <1% chance of flopping a flush; 11% chance of flopping a flush draw; 2% chance of flopping two pair; <1.5% chance of flopping trips using one of your hole cards, or a boat using both. I'm not positive on the odds of flopping a straight or OESD but I believe they are in the same neighborhood as flopping a flush or flush draw. Basically, about 5% of the time you'll have a great hand that can be bet heavily right from the start, and another 20% or so you'll have a solid draw that will require you to start calculating pot odds and implied odds. In those situations you obviously want to improve and win a large amount of money... that's maybe 1/4 of the time, based on the average odds of hitting a flush draw or OESD by the river, adjusted downward some because sometimes you'll have to fold without seeing both the turn and river cards (bad pot odds).

So let's just rough-estimate that 10% of the time you call a pre-flop raise with suited connectors or gapped cards, you'll eventually win the pot with a straight, flush, trips, or two pair. That means if you call a $1 raise pre-flop, you want to get at least $10 out of the hand (when you hit) to make it worth your while. Hopefully more than that, though. If you can destack someone for 20 or more times their pre-flop raise, you're doing your job. The important thing to remember is that a lot of the time, 80% or more, you're just going to end up folding. It takes some patience to do this right and not get caught up trying to steal a lot of pots that aren't available to take.

Of course, none of this factors in what we'll call the Rippy play: re-raising or calling down post-flop with a low pair only. You'll have a low pair a lot of the time. Choosing to play it against an aggressive player who is betting hard on overcards is a dangerous approach that is perhaps not for all temperaments. But it can clearly affect your profitability with these hands - for better or for worse.