It doesn't matter if there is only 1 player or 21 players, it's your equity to win (against all opponents) that matters. Use your favorite equity calculator and compare to pot odds.
I'd have a blasted hard time figuring exact equity against 2 villains' ranges, but I can easily figure, "I'm probably behind here and have n outs, which translates to ~2n% equity." Compare to pot odds and make the right choice.
EDIT: PRE the rule-of-2 doesn't apply so much, but when you have 2 outs per card, with 5 cards to see, there's ~2*2*5 = 20% chance to make a set, assuming no blockers.
I think JJ is an easy fold in this spot.
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