Obvious answer: It depends.

What type of player is this guy? Tight/passive? Tight/aggressive? Loose/aggressive? How many callers were there before him?

If he's a tight player, I'd say fold. You're probably an underdog to a preflop raise of any significant size by a tight player (though their position could factor in a bit as well...maybe they are trying to steal blinds). On the other hand, if they are loose, it's more iffy...I could go either way on it, but I'd still lean toward a fold. I'm assuming this person was the only person to raise.

- Jeffrey